Endocrine Abstracts

Background: Over the last few decades, in vivo animal experiments have been the gold standard for the assessment of safety of chemicals and pharmaceuticals for human health. However, in vivo animal data has limited relevance for toxicity prediction in humans, especially considering species-specific issues of age, sex and exposure in different life-stages. Within the Virtual Human Platform for Safety Assessment (VHP4Safety) project we aim to develop an animal-...

Efflux transporters in the blood–testis barrier (BTB) prevent entry and accumulation of xenobiotics in testis but are also involved in local transport of steroid hormones. Among these are the ATP-binding cassette (ABC) transporters, P-glycoprotein (P-gp/ABCB1) and multidrug resistance proteins 1 (MRP1/ABCC1) and 4 (MRP4/ABCC4). Here, we studied the interaction of suggested endocrine disruptors (EDCs) bisphenol A (BPA), tetrabromobisphenol A (TBBPA), bis(...